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Senior Scientist – ADC Development and CMC (f/m/d)

Permanent employee, Full-time · Planegg
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Werde teil unseres Teams
As a member of our CMC Process Development team, you will support and shape the development of innovative biopharmaceuticals and be responsible for contributing to the optimization, development, and execution of bioconjugation techniques and related processes. You will use a variety of preparation, purification, and characterization techniques relevant for the area of Antibody Drug Conjugates (ADCs) and protein drug conjugates. You will work in a highly interdisciplinary environment with the opportunity to learn and adopt new techniques.
Deine Aufgaben
  • Development and execution of bioconjugation studies with novel Antibody Drug Conjugates (feasibility, proof-of-concept, optimization, verification, lab scale-up)
  • Contribute to testing and bioanalytical characterization of the obtained conjugation products, enzymes and proteins
  • Conduct literature research and prepare conjugation, purification, and analysis plans
  • Maintaining clear and current documentation of the obtained results, writing SOPs and reports
  • Safe handling of HPAPI
  • Present written and oral reports to multidisciplinary teams
  • Contribute to the preparation and review of manufacturing and development documentation, such as batch records and reports
  • Contribute to DSP of various biomolecules, including enzymes, and proteins
Ihr Profil
  • You are highly motivated and independent with excellent communication and interpersonal skills. You feel comfortable effectively working in a dynamic and multidisciplinary team atmosphere
  • You have either a PhD in biotechnology, chemistry or biochemistry plus 3 years working experience, or Masters’ degree plus 5 years working experience in a pharmaceutical company. 
  • Relevant practical work experience in protein purification (affinity purification, ion-exchange or, hydrophobic interaction chromatography, TFF etc.).
  • Experience in DoE studies is a plus
  • Basic understanding of the quality principles that drive drug development, such as GMP 
  • Hands-on experience with protein analytics (HPLC, gel techniques, stability assessment, ELISA-assays, LC-MS etc.) is a benefit
  • Good proficiency in spoken and written English
  • Experience with Antibody Drug Conjugates or protein conjugates is a plus
Warum wir?
Flat hierarchies and short decision-making processes, open corporate culture, 30 days’ vacation, strong team spirit, multicultural team and high level of collegiality, team events, EGYM Wellpass, mobility allowance.
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Über uns
Die Behandlung von Krebserkrankungen gehört zu den größten Herausforderungen der modernen Medizin. Auf diesem Gebiet wollen wir etwas bewegen und wir möchte ein führendes Unternehmen für zielgerichtete Therapien werden. Mit einem starken Team, eigenen Technologien und innovativen therapeutischen Konzepten beschreiten wir neue Wege im Kampf gegen Krebs und teilen die Vision, Patienten weltweit helfen zu dürfen.
Be part of our team
As a member of our CMC Process Development team, you will support and shape the development of innovative biopharmaceuticals and be responsible for contributing to the optimization, development, and execution of bioconjugation techniques and related processes. You will use a variety of preparation, purification, and characterization techniques relevant for the area of Antibody Drug Conjugates (ADCs) and protein drug conjugates. You will work in a highly interdisciplinary environment with the opportunity to learn and adopt new techniques.
Your mission
  • Development and execution of bioconjugation studies with novel Antibody Drug Conjugates (feasibility, proof-of-concept, optimization, verification, lab scale-up)
  • Contribute to testing and bioanalytical characterization of the obtained conjugation products, enzymes and proteins
  • Conduct literature research and prepare conjugation, purification, and analysis plans
  • Maintaining clear and current documentation of the obtained results, writing SOPs and reports
  • Safe handling of HPAPI
  • Present written and oral reports to multidisciplinary teams
  • Contribute to the preparation and review of manufacturing and development documentation, such as batch records and reports
  • Contribute to DSP of various biomolecules, including enzymes, and proteins
Your profile
  • You are highly motivated and independent with excellent communication and interpersonal skills. You feel comfortable effectively working in a dynamic and multidisciplinary team atmosphere
  • You have either a PhD in biotechnology, chemistry or biochemistry plus 3 years working experience, or Masters’ degree plus 5 years working experience in a pharmaceutical company. 
  • Relevant practical work experience in protein purification (affinity purification, ion-exchange or, hydrophobic interaction chromatography, TFF etc.).
  • Experience in DoE studies is a plus
  • Basic understanding of the quality principles that drive drug development, such as GMP 
  • Hands-on experience with protein analytics (HPLC, gel techniques, stability assessment, ELISA-assays, LC-MS etc.) is a benefit
  • Good proficiency in spoken and written English
  • Experience with Antibody Drug Conjugates or protein conjugates is a plus
Why us?
Flat hierarchies and short decision-making processes, open corporate culture, 30 days’ vacation, strong team spirit, multicultural team and high level of collegiality, team events, EGYM Wellpass, mobility allowance.
Apply for this job
About us
The development of novel, effective and safe therapies for the treatment of cancer is one of the main challenges for modern medicine. We want to drive this process forward. The main goal of Tubulis is to become a leading company in the field of targeted therapeutics and antibody-drug conjugates (ADCs). With a strong team, our own technologies and innovative therapeutic concepts, we are ushering in a new era in the ongoing fight against cancer and share the vision of helping patients world-wide. Be part of a multidisciplinary and focused team, that works towards getting novel promising ADCs to patients with solid and hematological cancers.
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